Request Integrated Scientific Advice
Use this service to get Integrated Scientific Advice from the Medicines and Healthcare products Regulatory Agency (MHRA) and the National Institute for Health and Care Excellence (NICE). The MHRA and NICE have published guidance on the Integrated Scientific Advice (opens in new tab) it offers.
There is a fee to receive scientific advice. Find out about fees for the ISA service (opens in new tab).
Your application will be logged out if you are inactive for more than 24 hours. You will need to provide primary contact details, this email address will be used to save and return to your application.
If you choose to save and return, you will be able to return to this application at any point over the next 30 days and pick up where you left off.
Before you start
List of questions in this form
This form asks for detailed information about your request and requires you to upload documents. Most people find it helpful to gather everything they need before beginning.
To prepare in advance you can view a full list of the questions in the application form (opens in new tab).
Fees for advice
You won't need to pay anything when you submit your application. However, we will ask for your financial details to make sure we invoice you correctly.
If you're a small or medium-sized company (SME), you may be eligible for a reduced fee. To apply, you'll need to upload your SME approval letter from the MHRA. Find out how to apply for an SME fee reduction (opens in new tab).
After submitting the application
You will receive a copy of your application in an email. Once your application has been reviewed, the Integrated Scientific Advice team will contact you with information on the next steps.
If you have submitted the application form and need to add or change something, email scientific_advice@mhra.gov.uk and quote the application reference number provided.